Endocrine Abstracts

The endoplasmic reticulum (ER) is a cellular compartment specialized for chaperone-assisted folding and post-translational modification of nascent polypeptides. Disruption of ER homeostasis leads to accumulation of unfolded protein and activation of the unfolded protein response (UPR). The UPR emanates from the ER through activation of three transmembrane sensors, IRE1, PERK, and ATF6. IRE1 is a protein kinase / endoribonuclease that, upon activation, initiates a splicing reac...